Warfarin, Drug Reaction
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Warfarin, Drug Reaction| sufyan |
Posted: November 30, 2007 11:15 pm
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Taking History...  Group: Medical Students Posts: 29 Member No.: 1335 Joined: November 15, 2007  |
Hi there
 ,Warfarin is administered to a 56-year-old man following placement of a prosthetic cardiac valve. The warfarin dosage is adjusted to maintain an INR of 2.5. Subsequently, trimethoprim-sulfamethoxazole therapy is begun for a recurring urinary tract infection. In addition to monitoring prothrombin time, which of the following actions should the physician take to maintain adequate anticoagulation? (A) Begin therapy with vitamin K (B) Increase the dosage of warfarin © Make no alterations in the dosage of warfarin (D) Decrease the dosage of warfarin (E) Stop the warfarin and change to lowdose aspirin |
  
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| ali al-kafaji |
Posted: December 01, 2007 01:11 am
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Diagnosing... Group: Graduated Doctors Posts: 1576 Member No.: 22 Joined: August 14, 2005 |
decrease the dosage of warfarin (d)
thanks sufyans ali |
 
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| bloodstone |
Posted: December 01, 2007 01:50 am
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Diagnosing... Group: Graduated Doctors Posts: 1597 Member No.: 99 Joined: September 26, 2005 |
Decrease the dose..(to be honest..i cheated the answer
 )thx for your beneficial questions ,Sufyan&keep them on  |
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| sufyan |
Posted: December 01, 2007 08:45 pm
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Taking History... Group: Medical Students Posts: 29 Member No.: 1335 Joined: November 15, 2007 |
you both welcome
 and as u say answer is D and bloodstone, thanx for ur honesty |
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| Dr.Leo1984 |
Posted: December 06, 2007 03:34 pm
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Auscultating... Group: Graduated Doctors Posts: 839 Member No.: 68 Joined: September 08, 2005 |
can you explain why?..just for more benefit
thnx sufyan for your topics |
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| sufyan |
Posted: December 06, 2007 09:41 pm
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Taking History... Group: Medical Students Posts: 29 Member No.: 1335 Joined: November 15, 2007 |
because trimethoprin/sulfamethoxazole inhibit warfarin metabolism
I'm not quite sure about the cause and i will check it for u |
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