Hi there ,
Warfarin is administered to a 56-year-old man following placement of a prosthetic cardiac valve. The warfarin dosage is adjusted to maintain an INR of 2.5. Subsequently, trimethoprim-sulfamethoxazole therapy is begun for a recurring urinary tract infection. In addition to monitoring prothrombin time, which of the following actions should the physician take to maintain adequate anticoagulation?

(A) Begin therapy with vitamin K
(B) Increase the dosage of warfarin
© Make no alterations in the dosage of warfarin
(D) Decrease the dosage of warfarin
(E) Stop the warfarin and change to lowdose aspirin

decrease the dosage of warfarin (d)

thanks sufyans


ali

Decrease the dose..(to be honest..i cheated the answer )

thx for your beneficial questions ,Sufyan&keep them on

you both welcome
and as u say answer is D

and bloodstone, thanx for ur honesty

can you explain why?..just for more benefit

thnx sufyan for your topics

because trimethoprin/sulfamethoxazole inhibit warfarin metabolism
I'm not quite sure about the cause and i will check it for u