Hi, sorry for being late, but I just logged in:
Drug: Praziquantel (Biltricide ®) Drug Class: Antihelmintic
Mechanism of Action: increases the permeability of trematode & cestode cell membranes to calcium, resulting in paralysis, dislodgement & death.
Clinical Indications: Drug of choice for treatment of schistosome infections of all species & cestode infections, including cysticercosis.
Pharmacokinetics: tablets are taken with liquid after a meal, swallowed without chewing (because the bitter taste can cause retching & vomiting). Most of the drug is metabolized to inactive forms after a first pass in the liver. Half life is 0.8-1.5 hrs. Excretion is mainly via the kidneys (60-80%) and bile (15-35%).
Major drug Interactions: Cimetidine increases plasma levels of parziquantel. Phenytoin, carbamazepine & corticosteroids reduce it's bioavailability.
Further reading:
http://www.rxlist.com/cgi/generic2/praziquantel.htm (it shows the Description, make sure u go through other panels like Clinical Pharmacology, Indication & Dosage, etc.)
and for
CAFEGROT:http://www.rxlist.com/cgi/generic2/ergot.htmWish I could help